المنهاج الدراسي الخاص بكلية الصيدلة – كلية الصيدلة / جامعة كربلاء

All years practical



First stage
No.	lecture title	Lecture content	hours
1	Human Biology	The microscope	2
		The cells	2
		The tissues (Single epithelial tissue)	2
		Connective tissue	2
		Muscular tissue	2
		Nervous tissue	2
		Bone & Cartilage	2
		Digestive system(digestion)	2
		Digestive system (Small & Large intestine)	2
		Blood	2
		The Chromosome	2
		The Chromosome	2
		Cell division (Mitosis)	2
		Cell division (Meiosis)	2
		Excretory system	2
		Skin
		Skin	2
	Analytical Chemistry	Demonstration of some laboratory equipments.	2
		Separation and identification of group 1 cations	2
		(individual test).
		Analysis of group 1 cataions mixture.
		Analysis of group 1 cataions mixture.	4
		Preparation and standardization of an acid.
		Preparation and standardization of an acid.	2
		Determination of the percentage of acetic acid.
		Determination of the percentage of acetic acid.	2
		Analysis of sodium carbonate and sodium hydroxide mixture.	2
		Determination of chloride by the Mohr method.
		Determination of chloride by the Mohr method.	2
		Determination of chloride by the Volhard
		method.	2
		Preparation and standardization of 0.1N
		KMnO4.	4
		Determination of ferrous form of iron in Mohr’s salt.
		Determination of total hardness in tab water.
		Determination of total hardness in tab water.	2
		Gravimetric determination of Nickel.
		Gravimetric determination of Nickel.	4
	Human Anatomy	Directional term for Anatomy	2
		Skeletal system axial skeleton
		Skeletal system axial skeleton	2
		Skeletal system appendicular skeleton	2
		Skeletal system appendicular skeleton	2
		Appendicular muscles	2
		Axial muscles
		Axial muscles	2
		Joints of the body	2
		Circulatory system:	2
		Location of vascular system (Heart, Arteries, Veins)	2
		Digestive system:	2
		–location of different parts of digestive tract (GIT) (Oral cavity, Mouth, Esophagus & Stomach)
		-Small intestine, Large intestine, Rectum & Anus.

		Digestive system:
		Glands associated with the digestive tract by location (Salivary glands, Pancreas, Liver & Gall bladder).
			2
		Respiratory system:	2
		-Conducting portion (Nose, Nasopharynx, Trachea Bronchus & Bronchioles).
		-Respiratory portion (Lung)

		Urinary system:	2
		-location of the (kidney & nephrone)	2
		Nervous system:	2
		Central & Peripheral nervous system by location	2
	Medical Physics	Explain how to plot graph and make laboratory
		report.	2
		Optical Fiber Loss (bend) Measurement.
		Optical Fiber Loss (bend) Measurement.	2
		Simple pendulum.
		Simple pendulum.	2
		Spectral photometric
		Spectral photometric	2
		Density of liquid.
		Density of liquid.	2
6		The focal length of convex lens.
		The focal length of convex lens.	2
		application computer in medical physics
		application computer in medical physics	2
		Measurement of Viscosity of liquids.
		Measurement of Viscosity of liquids.	2
		Ostwald´s Viscometer: find viscosity of
		unknown; find the molecular
		weight; find concentration of unknown substance.	4
		Measuring surface tension (by capillary rise
		method and traveling microscope).
			2
		Measuring surface tension (differential height capillary method).

			2
		Decay curve and half life.
		Decay curve and half life.	2
		Boyle’s Law.
		Boyle’s Law.	2
		Speed of sound.
		Speed of sound.	2
		Laser application for measurement of single slit.
		Laser application for measurement of single slit.	2
	Histology	Circulatory system (Artery & Vein)	2
		Lymphatic system (Thymus gland & spleen)	2
		Lymphatic system (Lymph node & Islet of
		Langerhans)	2
		Nervous system (Cerebral & cerebrum cortex)	2
		Nervous system (Spinal cord)	2
		Respiratory system (Trachea & lung)	2
		Digestive system (Tongue, Esophagus &
		Stomach)	2
		Digestive system (Small & Large intestine)	2
		Digestive system Digestive system	2
		-Accessory glands of the digestive system (liver	2
		& Pancreas)
			2
7		Endocrine system (Pituitary & Thyroid gland)	2
		Endocrine system (Adrenal & pineal gland)	2
		Male reproductive system (Testes & prostate
		gland)	2
		Female reproductive system (Ovary & Uterus)	2
		Urinary system (Kidney & Urinary bladder)	2
		Skin (Thick & Thin skin)	2
	organic chemsitry I	Determination of melting point (Known sample).	2
		Determination of melting point (quiz and unknown).	2
		Determination of boiling point (known sample).	2
		Determination of boiling point (quiz and unknown).	2
		Elemental analysis (explanation of basic concepts).	2
		Elemental analysis (known quantity and quality sample).	2
		Solution and filtration techniques (explanation of basic concepts).	2
		Re-crystallization (known sample).	2
		Re-crystallization (quiz and unknown sample).	2
		Extraction technique (known sample).	2
		Extraction technique (quiz and unknown).	2
		Distillation techniques (known samples).	2
		Distillation techniques (quiz and unknown).	2
		Sublimation technique (known sample).	2
		Sublimation technique (quiz and unknown).	2
	Practical Pharmaceutical Calculation	Demonstration of different glass wares and equipments used in the field of pharmacy.	2
		Pharmaceutical measurements.	2
		Volume measurements.	2
		Preparation of aromatic waters.	4
		Preparation of simple solutions.	4
		Reducing and enlarging prescription contents.	6
		Percentages in calculating prescription contents.	4
		Stock solutions and dilution technique during dispensing technique.	6
	Computer science 1^st semester	· Home Tab	2
		· Modifying Spreadsheets
		· Move/Copy Cells
		· Insert Tab	2
		Ø Tables	2
		Ø Illustration	1
		Ø Charts	2
		Ø Create a Chart	1
		Ø Move Chart to New Sheet
		Ø Change Chart Name
		Ø Change Chart Layout	2
		Ø Change Chart Style
		Ø Chart or Axis Titles
		Ø Data Labels	2
		Ø Legend
		Ø Move or Resize Chart
		Ø Formatting an Excel Trendline
		Ø Reports	2
		Ø Sparklines	2
		Ø Filter	2
		Ø Links
		Ø Symbols
		· Formulas Tab	4
		Ø Function Library
		Ø Defined Names
		Ø Formula Auditing
		Ø Calculation	2
		· Data Tab
		Ø Data tab contains 5 groups:-
		1- Get external data	1
		2- Connections	1
		3 – Sort & filter	1
		4- Data Tools	1
		5- Outline	1
		· Add Data Analysis	2
		Ø T-test	2
	Computer science 2^st semester	Introducing Operating System Window 7	2
		Microsoft Office Professional 2010	2
		Introduction Microsoft Word 2010	2
		Microsoft Office Interface.
		File Ribbon Tab
		Microsoft Office Quick Access Toolbar
		Appearance of Microsoft Word
		Creating a New Document
		Opening a Document	2
		Home Tab	2
		Insert Tab – Inserting Objects	2
		Page Layout Tab – Document Layout	2
		References Tab	2
		Review Tab	2
		Mailings Tab – Mail Merge	2
		Introduction Power Point 2010	2
		Microsoft Office Interface.	2
		File Ribbon Tab	2
		Microsoft Office Quick Access Toolbar	2
		Appearance of Microsoft Word	2
		Creating a New Document	2
		Opening a Document	2
		Home Tab – Styling your Presentation	2
		Insert Tab – Inserting Objects	2
		Design Tab – Slide Layout
		Transitions Tab
		Animations Tab	2
		Slide Show Tab	2
		Review Tab	2

All years theoretical





	First stage

No.		Lecture title	Hours
		Biology	2
		Cell	2
		Tissues, bone and cartilages	3
		Nervous system (central & peripheral)	4
		Nutrition	2
		Digestive system (Mouth, Esophagus,
		Stomach)	2
		Digestive system (intestine)	1
		Excretory system & respiration	3
		Human genetics (chromosomes & semi- lethal genes)	3
1	Human Biology	Skin	2
		Circulatory system	3
		Immunity (Inflammation, immunity & the
		blood , immunity to disease)	3
	Principles of Pharmacy Practice	Some fundamentals of measurements and
		calculations.	4
		Interpretation of prescription or medication orders.	4
		The metric system.	4
		Calculation of doses.	4
		Reducing and enlarging formulas.	4
2		Density, specific gravity and specific volume.	4
		Percentage and ratio strength calculation.	6
		Review of elementary concept important to
		analytical chemistry: Strong and weak electrolytes; important weight and concentration units.	4
		The evaluation of analytical data: Definition of terms
3	Analytical Chemistry	An introduction to gravimetric analysis: Statistical
		analysis of data; rejection of data; precipitation methods; gravimetric factor.	9
		The scope of applications of gravimetric analysis:
		Inorganic precipitating agents; organic precipitating agents.	4
		An introduction to volumetric methods of analysis: Volumetric calculations; acid-base equilibria and pH calculations.
			5
		Buffer solutions: Theory of neutralization titrations
		of simple system.	3
		Theory of neutralization titrations of complex
		system; Precipitation titrations.	5
		Calculation of pH in complex system; Volumetric
		methods based on complex system.	4
		Equilibria in oxidation-reduction system; theory of
		oxidation-reduction titrations.	6
		Spectrophotometric analysis: An introduction to
		optical methods of analysis; Methods based on absorption of radiation.	4
		Mathematics: General concepts; coordinate and graph in plane;
		inequality; absolute value or magnitude; function and their graphs;
		displacement function; slope and equation for lines.	6
		Limits and continuity: Limits; theorem of limits; limit involving
		infinity; continuity; continuity conditions.
			4
		Derivatives: Line tangent and derivatives;
		differentiation rules;
		derivative of trigonometric function; practice exercises.	6
	Mathematics and Biostatistics	Integration: Indefinite integrals; rules for indefinite
		integrals; integration
		formulas for basic trigonometric function; definite integrals; properties of definite integrals; practice exercises.
			6
		Biostatistics: General concepts of statistics;
		statistical methods;
		statistical theory; applied statistics; statistical operations.	2
		Probability concepts: Properties of probability; Set
		theory and set
		notation (basic notation); counting techniques- permutations and combinations; calculating the probability of an events; probability distribution of discrete variable; binomial distribution, Poisson distribution; continues probability distribution and normal distribution, review questions and exercises.	6
		The concept of central tendency: Mean of sample and mean of
		population; median; mode; measure of central tendency; review questions and exercises.	6
		Deviations and variation: Deviation; dispersion and
		variability; standard
		deviation and variance; coefficient of variations; standard error; correlation analysis.(regression model and sample regression equation); application of statistic in medical field; review questions and exercises.	9
	Medical Terminology	Basic word roots and common suffixes	1
		More word roots, suffixes and prefixes related to pharmaceutical sciences (pharmacognosy, clinical pharmacy, pharmaceutics,…etc)

			1

		Basic anatomical terms and abnormal conditions	2
		The genitals and urinary tract	1
		The gastrointestinal tract	1
		The heart and cardiovascular system
		The heart and cardiovascular system	1
		Symptoms, diagnoses, treatments, communication
		qualifiers, and statistics	2
		Growth and development, and body orientation	1
6		Gynecology, pregnancy, and childbirth	1
		The eye and the respiratory tract	1
		The nervous system and behavioral disorders	2
		Blood and immunity	1
		Circulatory system:
		Location of vascular system (Heart, Arteries, Veins)	1

		Circulatory system:
		Location of lymphatic system (Lymphatic capillary).	1
		Lymphoid tissue:
		location of the (Thymus gland, Spleen & Lymph nodes)	1
		Lymphoid nodule (MALT) & Tonsils	1
		Nervous system:
7	Human Anatomy	Central & Peripheral nervous system by location	1
		Respiratory system:
		-Conducting portion (Nose, Nasopharynx, Trachea Bronchus & Bronchioles).
		-Respiratory portion (Lung)	1
		Digestive system:
		–location of different parts of digestive tract (GIT) (Oral cavity, Mouth, Esophagus & Stomach)
		-Small intestine, Large intestine, Rectum & Anus.
			2
		Digestive system:
		Glands associated with the digestive tract by location (Salivary glands, Pancreas, Liver & Gall bladder).
			1
		Endocrine system:
		-location of the pituitary gland
		–location of the Adrenal, Thyroid, Parathyroid, Islet of Langerhans & Pineal glands.	1
		Male reproductive system:
		–location of the testes.	2
		-Excretory genital ducts
		-Excretory genital glands (Seminal vesicles, Prostate & Cowper’s glands)
		Female reproductive system:
		-location of ovary, Oviduct, Uterus & Vagina.	2
		Urinary system:
		-location of the (kidney & nephrone)	1
		– location of the (Ureter, Bladder & Urethra).
		Dilution and concentration of pharmaceutical
		preparations.	10

	Pharmaceutical Calculations by Stoklosa	Isotonic solutions.	6
		Electrolyte solutions (milliequivalents, millimoles and milliosmoles).
8			6
		Constituted solutions, I.V admixtures and flow rate
		calculations.	8
		General concepts: Method of physics and
		standards; thermodynamics
		system and system properties; conservation of energy principle;
		application of thermodynamics; the Zeroth law.	3

		Pressure; temperature and temperature scales
		(Celsius, Fahrenheit,
9	Medical Physics	Kelvin); equation of state; ideal gas and real gas; general law of gases; clauses equation and Vander Waales equation; equilibrium and types of equilibrium; compressibility factor, coefficient of volume expansion, elastic coefficient (bulk modulus).	6
		Heat and energy; work and mechanical forms of
		work; power; the 1st
		law of thermodynamics; Boyles and Charles law; practice exercises.	3
		The 2nd law of thermodynamics; reversible and
		irreversible process;
		entropy and enthalpy; internal energy; heat capacity and adiabatic process; the relation between pressure, volume, and temperature in adiabatic process.
			6
		Fundamental of physics: Kinetic theory of a gas; electromagnetic waves;
		Maxwell equations; physical optics.	6
		Radiation: Kirshoffs law; planks law; Stefan-
		Boltzman law; Wiens law;
		Black body and Albedo; Heat transfer (radiation, convection, conduction).	6
		Production of X-Ray and X-Ray spectra; absorption
		of X-Ray; U.V and
		IR effects; medical and biological effects of radiation; radiotherapy.	3
		Introduction.	3
		Alkanes and methane.	6
		Alkenes I and II	5
		Alkynes and dienes.	5
		Stereochemistry I & II	8
		Alcohols and ethers.	8
10	Organic Chemistry I	Alkyl halides.	6
		Cycloalkanes.	4
		Circulatory system:
		Structure of the vascular system (Heart wall, Arteries, Veins & Capillaries)	2
		Circulatory system:
		Structure of the lymphatic system (Lymphatic capillary).	1
		Lymphoid tissue:
		Structure & function of the (Thymus gland, Spleen	1
		& Lymph nodes)
		Lymphoid nodule (MALT) & Tonsils	1
11	Histology	Nervous system:
		Central & Peripheral nervous system	3
		Respiratory system:
		-Conducting portion (Nose, Nasopharynx, Trachea Bronchus & Bronchioles).
		-Respiratory portion (Lung)	3
		Digestive system:
		–Digestive steps.
		–General structure of the digestive tract (GIT) (Oral cavity, Mouth, Esophagus & Stomach)
		-Small intestine, Large intestine, Rectum & Anus.	3
		Digestive system:
		Glands associated with the digestive tract (Salivary glands, Pancreas, Liver & Gall bladder0.	1
		Endocrine system:
		-General structure of the pituitary gland	2
		-Histophysiologies of the pituitary gland.
		Endocrine system:
		-General structure of the Adrenal, Thyroid,
		Parathyroid, Islet of Langerhans & Pineal glands.	2
		Male reproductive system:
		–General structure of the testes.
		-Stages of spermatogenesis.	2
		Male reproductive system:
		-Excretory genital ducts-Excretory genital glands	1
		(Seminal vesicles, Prostate & Cowper’sglands)
		Female reproductive system:
		-General structure of ovary, Oviduct, Uterus & Vagina.
		-Stages of follicle development.
		-Ovulation	3
		Urinary system:
		-Structure & Function of the (kidney & nephrone)
		-Histology of the nephrone (filtration, absorption & excretion).
		– Structure of the (Ureter, Bladder & Urethra).	3
		The skin
		Thick & Thin skin	2
		Hello	2
		Hello	2
		Your world	2
		All about you	2
	English (John and Liz Soars, New Headway Plus, Oxford: Oxford	Family and friends	2
		Family and friends	2
		The way I live	2
		Every day	2
		My favorites	3
		Where I live	2
		Times past	2
		We had a great time	2
		I can do that	2
		Please and thank you	2
		Here and now	3
		Its time to	2








	Second stage
		Lecture title
		Lecture title	hours
		Aromatic Hydrocarbons (includes benzene, electrophilic aromatic substitution, arenas and their derivatives).	10
		Carboxylic acids: properties and reactions.	5
		Functional derivatives of carboxylic acids.
		Functional derivatives of carboxylic acids.	7
		Amines I and II.	6
1	Organic Chemistry II	Aldehydes and ketones (include also aldol and Claisen
		condensation); Classification, reactions and properties.	12
		Phenols.	5
		Introduction: Importance of microbiology, History of microbiology	2
		Anatomy of bacteria: Surface appendages, Capsule, Cell wall of
		G.+ve & G –ve bacteria, Cytoplasmic membrane.
			2
		Bacterial physiology: Physical and chemical growth determinate, growth and growth curves, bacterial reproduction.	3


		Genetics: Definition, genetic, element, mutation (spontaneous,	2
		Gene transfer, transformation, conjugation, and gene transduction).

		Recombinant DNA biotechnology.
	Medical Microbiology,	Recombinant DNA biotechnology.	1
		Sporulation and germination.
		Sporulation and germination.	1
		Sterilization (chemical + physical Methods).
		Sterilization (chemical + physical Methods).	2
		Chemotherapy and sensitivity test
		Chemotherapy and sensitivity test	3
		Staphylococci species
		Staphylococci species	3
		Streptococcus species

			3
		Aerobic Spore-forming bacteria Bacillus species (B. anthracis, B.
		subtilis, B. cereus).
			2
		Clostridium perfringens; Clostridium tetani; Clostridium botulinun
			3
		Corynebacterium diphtheriae
		Corynebacterium diphtheriae	2
		Propionibacterium acnes, Listeria
		Propionibacterium acnes, Listeria	2
		Mycobacterium tuberculosis; M. leprae
		Mycobacterium tuberculosis; M. leprae	2
		Enterobacteriaceae: (E. coli; Klebsiella spp.; Citrobacter , Serratia, Salmonella, Shigella)
			6
		, Vibrio, Pseudomonas, Helicobacter pylori, Neisseria spp., Brucella, Proteus,
			6
		The general and cellular basis of medical physiology.	5
		Physiology of nerves and muscles: Nerve cells; excitation	16
	: Physiology I	and conduction; Properties
		of mixed nerves; glia; neurotrophins; Nerve fiber types and functions; Muscles: Skeletal muscle; smooth muscle; cardiac muscle. Synaptic transmission: Reflexes; cutaneous, deep and visceral sensations; alert behavior, sleep and electrical activity of the brain; control of posture and movement; higher function of the nervous system; central regulation of visceral function; the autonomic nervous system.
		Respiration: Respiratory zones; Mechanics of respiration; air	8
		volumes; respiratory
		muscles; compliance of the lungs and chest wall; surfactants; differences in ventilation and blood flow in deferent parts of the lung; Dead space and uneven ventilation; Pulmonary circulation: Pressure, volume and flow. Gas transport between the lungs and tissue; Regulation of respiration: Neural control of breathing;
		Respiratory centers; Regulation of respiratory activity: Chemical factors; non chemical factors; Respiratory adjustment in health and disease; Effect of exercise; Hypoxia; Emphysema; Asthma.
		Renal Physiology: Introduction; innervations of the renal	8
		vessels; renal clearance;
		renal blood flow; glomerular filtration rate (GFR): Measurements; factor affecting GFR; Filtration fraction; reabsorption of Na+, Cl – and glucose. Tubuloglomerular feedback and glomerulotubular balance; water excretion in: proximal tubules; loop of henle; distal tubules; collecting ducts; the counter current mechanism; role of urea; water diuresis and osmotic diuresis; acidification of the urine: H+ secretion; reaction with buffers; ammonia secretion; factors affecting acid secretion; bicarbonate execration; regulation of Na+, K+ and Cl – excretion; uremia; acidosis; micturition.
		Cardiovascular system: origin and spread of cardiac	8
		excitation; the electrocardiogram;
		cardiac arrhythmias; electrographic findings in cardiac diseases; mechanical events of the cardiac cycle; cardiac output; cardiovascular regulatory mechanisms: Local regulatory mechanisms; systemic regulation by the nervous system; systemic regulation by hormones; Coronary circulation; Hypertension; Heart failure; Angina pectoris.
		States of matter, binding forces between molecules, gases,	10
		liquids, solid and crystalline matters; phase equilibria and phase rule; thermal analysis.
		Thermodynamics, first law, thermochemistry, second law,	8
		third law, free energy function and applications.
		Solutions of non-electrolytes, properties, ideal and real	7
		Colligative properties, molecular weight determination.
	Physical Pharmacy I	Solution of electrolytes, properties, Arrhenius theory of	5
		dissociation, theory of strong electrolytes, ionic strength, Debye-Huchle theory, coefficients for expressing colligative properties.
		Ionic equilibria, modern theories of acids, bases and salts,	8
		acid-base equilibria, calculation of pH, acidity constants, the effect of ionic strength and free energy.
		Buffered and isotonic solutions: Buffer equation; buffer	7
		capacity; methods of adjusting tonicity and pH; buffer and biological system.
		Heterocyclic system: Classes of heterocyclic systems;
		general structures; properties; Occurrence in nature and in medicinal products.	5


		Five-membered ring heterocyclic compounds: pyrrole; furan
		and thiophen.	3
		Source of pyrrole, furan and thiophen.	2
		Electrophilic substitution in pyrrole, furan and thiophen:
		Reactivity and orientation.	5
	Organic ChemistryIII	Six-membered ring heterocyclic compounds: Structure &
		reactions of pyridine.	4
		Saturated five-membered heterocyclic compounds.	6
		Heterocyclic of five & six member rings with two & three
		heteroatoms.	5
		Introduction.	1
		Intestinal and tissue protozoa (Amoeba (pathogenic and non pathogenic), Balantidium, Giardia, Trichomonas	4
		Chilomastix)
	Medical Virology, immunology, and Parasitology	Haemoflagellates: Leishmania spp.; Trypanosome spp.	4
		Sporozoa: Malarial parasites of human; Toxoplasma.	3
		Helminthes: Classification, Cestodes (Hymenolepis nana, Taenia spp.), Echinococcus (Hydatid cyst).	8
		Hepatic flukes, Trematodes (Blood Flukes: Schistosoma spp).
		Nematods: Ascaris, Entrobius. Trichuris, Ancylostoma, Necator americans.
		Virology: Introduction, Comparison between viruses and	10
		Bacteria and other microbes; origin of viruses, reproduction, one step growth curve, type of mutations and Classification of viruses; RNA viruses: Orthomyxo viruses; Paramyxo viruses; Retro viruses; Hepato viruses; Oncogenic viruses. DNA viruses: Herpes viridae; poxviradeae, adenoviredeae, parvoviruses
		Immunology: introduction, innate and adaptive immunity, complement, MHC molecule and autoimmune diseases, hypersensitivity, tumor immunity, immunodeficiency, immunological methods.	15
		Solubility and distribution phenomena, solvent-solute	10
		interactions,
		solubility of gases in liquids, solubility of liquids in liquids, solubility of non-ionic solids in liquids, distribution of solutes between immiscible solvents.
		Complexation, classification of complexes, methods of	5
		analysis,
		thermodynamic treatment of stability constants.
		Kinetics, rate and orders of reactions, influence of	9
		temperature and other
		factors on reactions rate, decomposition of medicinal agents and accelerated stability analysis.
	Physical PharmacyII by Alfred Martin et a	Interfacial phenomena, liquid interfaces, surface free energy,	5
		measurement of interfacial tension, spreading coefficient, surface active agents and wetting phenomena.
		Colloids, dispersed system and its pharmaceutical	5
		application, types of
		colloidal systems, kinetic properties, diffusion, zeta potential, solubilization.
		Micrometrics, particle size, methods of determining particle	3
		size, particle shape and surface area, porosity, density.
		Rheology, Newtonian systems, thixotropy measurement,	5
		Negative thixotropy, determination of thixotropy.
		Polymer science, definitions pharmaceutical applications,	3
		molecular eight averages.
		Gastrointestinal function: Digestion and absorption of	10
		carbohydrates; proteins; lipids; absorption of water and electrolytes; vitamins and minerals; regulation of gastrointestinal function: Introduction; gastrointestinal hormones; mouth and esophagus; stomach; exocrine portion of the pancreas; liver and biliary system; small intestine; colon.
		Circulatory body fluid: Introduction; blood; bone marrow;	15
	Physiology II	white blood cells; immunity; platelets; red blood cells; anemia; polycythemia; blood group and Rh factor; hemostasis: The clotting mechanism / blood coagulation tests; anti clotting mechanism; the plasma; the lymph; abnormalities of hemostasis.
		Endocrinology: Introduction; energy balance, metabolism	20
		and nutrition; the pituitary gland; the thyroid gland; the gonads: development and function of the reproductive system; the adrenal medulla and adrenal cortex; hormonal control of calcium metabolism and the physiology of the bone; endocrine functions of the pancreas and regulation of carbohydrate metabolism.
		Getting to know you.	2

		The way we live	2
		It all went wrong	2
		Let’s go shopping	2
		What do you want to do?	2
		Tell me! What’s it like?	2
	English	Famous couples	2
		Do’s and Don’ts	2
	Liz and John Soar, New Headway Plus – Pre-Intermediate. Oxford: Oxford University Press	Going places	2
		Scared to death	2
		Things that changed the word	3
		Dreams and reality	3
		Earning living	2
		Love you and leave you	2
		General Introduction: The Scope of Pharmacognosy,	3
		definitions and basic principles.
		Drugs from natural sources, crud drugs, official and non-	1
		official drugs.
		Classification of natural products.	2
		Plant nomenclature and taxonomy.	2
		Production of crude drugs: Cultivation, collection, drying	3
		and storage.
		Deterioration of crude natural products.	1
		Chemistry of natural drug products.	3
		Quality control: Evaluation of natural products;	4
	Pharmacognosy I	macroscopical evaluation; physical evaluation; chemical evaluation; biological evaluation; spectroscopical evaluation.
		Phytochemical investigation of herbal products: Extraction	4
		of the plant material; Separation and isolation of constituents; characterization of the isolated compounds.
		Separation technique: Introduction; Mechanisms of	15
		separation and classification based on the type of technique; paper chromatography; Thin layer chromatography; Ion- exchange chromatography; Gel filtration chromatography; Column chromatography; Gas chromatography; HPLC; Electrophoresis; Affinity chromatography.
		Traditional plant medicines as a source of new drugs.	3
		Bioassay-guided fractionation

	Third stage
	ةداملا	Lecture title

			hours
		Atomic and molecular structure/ Complexation.	6
		Essential and trace ions: Iron, copper, sulfur, iodine.	3
		Non essential ions: Fluoride, bromide, lithium, gold, silver and
		mercury.	2
		Gastrointestinal agents: Acidifying agents.	1
		Antacids.	2
		Protective adsorbents.	1
		Topical agents.	2
	Inorganic Pharmaceutical Chemistry	Dental agents.
			1
		Radiopharmaceutical preparations.	6
		Radio opaque and contrast media.	6
		Introduction: General biosynthesis pathways of secondary
		metabolites.	2
		Carbohydrates.
			2
		Glycosides: Biosynthesis, physical and chemical properties; cardiac
	Pharmacognosy II	glycosides; saponin glycosides; anthraquinone glycosides; flavonoid glycosides; cyanophore lycosides.	5
		Glycosides: Isothiocyanate glycosides; aldehyde glycosides; alcoholic
		glycosides; phenolic glycosides; lactone glycosides; coumarins and chromones.	5
		Resins and resin combination; tannins.
			2
		Lipids: fixed oils and waxes.
			3
		Volatile oils: Introduction; chemistry of volatile oils; biosynthesis of
		volatile oils; hydrocarbons as volatile oils; alcohols as volatile oils; aldehydes as volatile oils.	4
		Ketones as volatile oils; Phenols as volatile oils; Oxides as volatile
		oils; Ester as volatile oils; Phenolic ethers as volatile oils.	3
		Non- medicinal toxic plants.	2
		Vitamins and Amino acids.
			2
		Dispersed systems: their classification; comparisons between	2
		different systems.
		Solutions and types of solutions.	2
		Solubility: Factors affecting solubility; expression of dissolution;	4
		dissolution rate versus solubility; preparation of solutions containing non-volatile materials.
		Official solutions; classification of official solutions; preparation and	4
		uses.
		Aqueous solutions containing aromatic principles; aromatic waters;	4
		methods of preparations; stability.
		Syrups: sugar based syrups; artificial and sorbitol based syrups;	4
		stability of syrups.
		Definition and methods of clarification; filter aids in clarification.	3
	Pharmaceutical Technology I	Preparation of solutions using mixed solvent systems; spirits, and	3
		elixirs.
		Extraction; maceration and percolation.	3
		Tinctures; fluid extracts; extracts of resins and oleoresins.	4
		Colloidal dispersions; lyophilic; lyophobic.	6
		Coarse dispersion; suspensions.	6
		Introduction to the macromolecules biochemistry: Definitions and	2
		terms; proteins, enzymes, DNA; Clinical value.
		Amino acids: Structures of A.A (table of standard A.A abbreviation	3
	Biochemistry I	and
		side chain); Classification, properties, isomerism.
		Amino acids: Chemical reactions, Zwitter ions, titration curve
		calculating isoelectric point values. Examples and questions. Non standards A.A: Structures, existence and clinical value.	3
		Peptides: Peptide bond, resonance forms, isomers, physical properties
		and chemical reactions. Essential poly peptides in human body, structures, roles and clinical values.	3
		Proteins: Structure and conformations of proteins, Primary structure,
		Secondary structure (4 helix, 5 sheet), tertiary structure, quaternary structure. Classification, synthesis, cellular functions (Enzymes, cell signaling, and ligand transport, structural proteins), protein in nutrition.	3
		Denaturation of proteins and protein sequencing: Determining A.A	3
		composition, N- terminal A.A analysis, C- terminal A.A analysis, Edman degradation, prediction protein sequence from DNA/ RNA sequences. Methods of protein study: Protein purification, cellular localization, proteomics and bioinformatics, structure predication and simulation.
		Carbohydrates: Chemistry and classification, biomedical importance,	3
		classification of CHO, Stereochemistry of monosaccharides, metabolism of CHO; Physiologically important monosaccharides, glycosides, disaccharides, polysaccharides.
		Lipids: Introduction, classification of lipids, fatty acids (F.A),	3
		nomenclature of F.A, saturated F.A, unsaturated F.A, physical and physiological properties of F.A, metabolism of lipids. Phospholipids, lipid peroxidation and antioxidants, separation and identification of lipids, amphipathic lipids.
		Enzymes: Structures and mechanism, nomenclature, classification,	3
		mechanisms of catalysis, thermodynamics, specificity, lock and key model, induced fit model, transition state stabilization, dynamics and function, allosteric modulation. Biological function, cofactors, coenzymes, involvement in disease.
		Kinetics: General principles, factors effecting enzyme rates (substrate	2
		conc., pH, temperature, etc), single-substrate reaction (Michaelis- Menten kinetics), kinetic constants. Examples of kinetic questions and solutions.
		Enzyme inhibition: Reversible inhibitors, competitive and non	1
		competitive inhibition, mixed-type inhibition, Irreversible inhibition. Inhibition kinetics and binding affinities (ki), questions and solutions.
		Control of activity and uses of inactivators; multi-substrate reactions,	1
		ternary-complex mechanisms, ping-pong mechanisms, non- Michaelis- Menten kinetics, pre-steady-state kinetics, chemical mechanisms.
		Nucleic Acid: Chemical structure, nucleic acid components, nucleic	3
		acid bases, nucleotides and deoxynucleotides (Properties, base pairing, sense and antisense, super-coiling, alternative structures, quadruple structures.
		Biological functions of DNA: Genes and genomes, transcription and	2
		translation, replication.
		Biochemistry of extracellular and intracellular communication:	3
		Plasma
		membrane structure and function; Biomedical importance, membrane proteins associated with lipid bilayer, membranes protein composition, dynamic structures of membranes, a symmetric structures of membranes.
		Artificial membranes model, the fluid mosaic model, membrane	1
		selectivity, physiological functions of plasma membranes.
		Biochemistry of the endocrine system: Classification of hormones,	3
		biomedical importance, the target cell concept and hormone receptors, biochemistry of hormone action and signal transduction.
		Special topics: Nutrition, digestion, and absorption. Biomedical	3
		importance, digestion and absorption of carbohydrates, lipids, proteins, vitamins and minerals; energy balance. Biochemistry of hemostasis and clot formation.
		Introduction.	1
		Cell injury and tissue response; Degeneration; Necrosis; Atrophy;	6
		Hypertrophy; Metaplasia and Calcification; Inflammation and Repair.
		Disorders of electrolytes and water and acid–base balances: Hyper	4
		and
	Pathophysiology	Hyponatremia; Hyper and Hypokalemia; Syndrome of inappropriate secretion of ADH; Diabetes insipidus; Metabolic acidosis and alkalosis; Respiratory acidosis and alkalosis.
		Disorders of cardiovascular system: Hyperemia; Congestion and	5
		edema;
		Thrombosis; embolism and infarction; Shock; Coronary heart disease and MI; Rheumatic heart disease; Heart failure; Acute pulmonary edema; Essential hypertension; Secondary hypertension; Malignant hypertension; Hypotension; Aneurysm versus varicose veins;
		Disorders of respiratory system: Pneumonias; Tuberculosis;	3
		Respiratory
		distress syndrome; Bronchial asthma; Emphysema and bronchiectasis; Cystic fibrosis; Pulmonary embolism; Pulmonary hypertension.
		Disorders of the renal system: Nephrotic syndrome;	4
		Glomerulonephritis;
		Diabetic glomerulosclerosis; Hypertensive glomerular disease; Pyelonephritis; Drug related nephropathies; Acute renal failure; Chronic renal failure.
		Disorders of GI and hepatobiliary systems: Peptic ulcer and Zollinger	4
		–Ellison syndrome; Irritable bowel syndrome; Crohn’s disease; Diarrhea; Celiac disease; Viral hepatitis; Primary biliary cirrhosis; Liver failure; Cholelithiasis.
		Disorders of thyroid function: Hypothyroidism. Hyperthyroidism.	2
		Graves’s disease. Thyrotoxicosis.
		Disorders of adrenal function: Cushing syndrome. Adrenal cortical	2
		Insufficiency (primary and secondary). Congenital adrenal hyperplasia. Pheochromocytoma.
		Diabetes mellitus and metabolic syndrome;	3
		Dyslipoproteinemia.	2
		Neoplasia	4
		Metabolic &rheumatic disorders of skeletal system:	2
		-Osteoporosis, osteomalacia & rickets, rheumatoidarthritis, systemic lupus erythromatosus, ankylosing spondylitis, gout, osteoarthritis syndrome.
		Alterations in the immune response (pathophysiology of immunopathology):
		– Hypersensitivity disorders.
		– Transpalantation immunopathology.	3
		– Immunodeficiency disorders.
		Drug distribution.	4
		Acid- base properties.	3
		Statistical prediction of pharmacological activity.	3
		QSAR models.	2
		Molecular modeling (Computer aided drug design).	1
		Drug receptor interaction: force involved.	1
		Steric features of drugs.	2
		Optical isomerism and biological activity.	1
		Calculated conformation.	1
		Three- dimensional quantitative structure activity relationships and	1
		databases.
		Isosterism.	1
		Drug-receptor interaction and subsequent events.	1
	Organic Pharmaceutical Chemistry I	General pathways of drug metabolism: Sites of drug	22
		biotransformation; Role of cytochrome P450 mono-oxygenases in oxidative biotransformation; Oxidative reactions; Reductive reactions; Hydrolytic reactions; Phase II reactions.
		Factors affecting drug metabolism.	2
		General introduction to Pharmacology.	2
		Pharmacokinetics.	4

	pharmacology I	Drug Receptor interaction and Pharmacodynamics.	4
		The autonomic nervous system (ANS).	2
		Cholinergic system.	6
		Adrenergic system.	6
		Principal of antimicrobial therapy.	2
		β- lactam and other cell wall synthesis inhibitor antibiotics	4
		Protien synthesis inhibitors	4
		Quinolones, Folate antagonists, and urinary tract antiseptics.	3
		Antimycobacterium drugs	2
		Antifungal drugs.	2
		Antiprotozoal drugs.	1
		Anthelmintic drugs.	2
		Antiviral drugs.	1
		Emulsions; purpose of emulsification; methods of emulsification;	10
		emulsifying agents; HLB system; stability of emulsions.

		Lotions; liniments and collodions.	5
		Suppositories.	6
		Powdered dosage forms.	10
		Semisolid dosage forms.	10
	Pharmaceutical Technology II	Incompatibilities in pharmaceutical dosage forms.	4
		Bioenergetics.	2
		Biologic oxidation.	2
		The respiratory chain and oxidative phosphorylation.	2
		Over view of metabolism.	2
		Citric acid Cycle.	2
		Glycolysis.	2
		Metabolism of glycogen.	4
		Gluconeogenesis.	3
		Pentose phosphate pathway and other pathways of hexose	3
	Biochemistry II	metabolism.
		Biosynthesis of fatty acids.	3
		Oxidation of fatty acids.	2
		Metabolism of acylglycerol and sphingolipids.	2
		Lipid transport and storage.	2
		Cholesterol synthesis, transport, and excretion.	2
		Biosynthesis of the Nutritionally Nonessential Amino Acids.	3
		Catabolism of Proteins & of Amino Acid Nitrogen	3
		Catabolism of the Carbon Skeletons of Amino Acids.	2
		Conversion of Amino Acids to Specialized Products.	2
		Porphyrins & Bile Pigments	2
		Alkaloids: Introduction; Physical and chemical properties; pyridine,	5
		piperidine alkaloids; tropane alkaloids.
		Alkaloids: Quinoline tropan alkaloids; iso-quinoline alkaloids;	5
		imidazole alkaloids; indole alkaloids.
		Alkaloids: Steroidal alkaloids; lupinane alkaloids; alkaloidal amines;	4
	Pharmacognosy III	purine alkaloids.
		Antibiotics: Natural sources; biosynthetic pathways, isolation and	6
		purification.
		.phytotherapy :Introduction , principles,medicinal plants in selected	10
		health care systems.Important natural products & phytomecines used in pharmacy & medicine
		Introduction to Pharmacy Ethics (Theoretical considerations).	2
		Code of Ethics for Pharmacists.	1
		Common Ethical Considerations in Pharmaceutical Care Practice
		(Beneficence, Autonomy, Honesty, Informed Consent, Confidentiality, Fidelity ………).	3
		Interprofessional Relations.	2
		Making ethical decisions.	1
		Ethical issues related to clinical pharmacy research.	1
		Ethical problems in the pharmacist’s clinical practice.	1
		Preventing misuse of medicines.	1
		Case studies in pharmacy ethics.	3


	Fourth stage
		Lecture title	hours
	Pharmacology II	Introduction to CNS pharmacology.	2
		CNS stimulants.	2
		Anxiolytic and Hypnotic drugs.	3
		General and Local Anesthetics.	3
		Antidepressant drugs.	3
		Antipsychotic (neuroleptic) drugs.	3
		Opioid analgesics and antagonists.	3
		Treatment of neurodegenerative diseases.	3
		Antiepileptic Drugs.	2
		Diuretics.	2
		The treatment of heart failure (HF).	2
		Antiarrhythmic drugs.	2
		Antianginal Drugs.	2
		Antihypertensive drugs.	3
		Drugs affecting the blood.	3
		Antihyperlipidemic drugs.	2
		Gastrointestinal and antiemetic drugs.	2
		Drugs acting on the respiratory system.	3
		Cholinergic agents, cholinergic receptors and their subtypes.	3
		Cholinergic agonists; stereochemistry and structure-activity	5
		relationships (SAR); products; cholinesterase inhibitors.
	organic pharmaceutical chemistry	Cholinergic blocking agent; structure-activity relationships (SAR);	5
		Solanaceous alkaloid and analogues; synthetic cholinergic blocking agents and products; ganglionic blocking agents (neuromuscular blocking agents).
		Analgesic agents (SAR of morphine, SAR of meperidine type	5
		molecules; SAR of methadone type compounds; N- methylbezomorphans, antagonist type analgesics in benzomorphans).	5
		Analgesic receptors, endogenous opioids; Products; Antitusive	5
		agents; Anti-inflammatory analgesics.
		Adrenergic agents (Adrenergic neurotransmitters); Adrenergic	8
		receptors; Drugs affecting Adrenergic neurotransmission; Sympathomimetic agents; Adrenergic receptor antagonists.
		CNS depressant; Benzodiazepines and related compounds;	7
		Barbiturates; CNS depressant with skeletal muscle relaxant properties; Antipsycotics; Anticonvulsants.
		CNS Stimulants	3
		Steroidal & nonsteroidal hormones	4
		Introduction to community pharmacy.	1
		Respiratory problems: Cough, Common cold, allergic rhinitis, Otitis media, Laryngitis & Pharyngitis
			3
		G.I.T problemse: Diarrhea, Constipation, Heart burn and indigestion, IBS and Hemorrhoids
			4
		Pediatric care practice : Oral thrush, pinworms and head lice	2
		Skin conditions: Acne, Scabies, Psoriasis, Hair loss, Fungal
		infection, Eczema and Dermatitis , Dandruff, Cold sore, Corns and Callus.	5
		Women’s health care: Cystitis and vaginal thrush, primary
		dysmenorrhea and Premenstrual syndrome.
			2
		CNS related problems: Headache, Insomnia, Motion sickness, Nausea and vomiting	3
		– Eye problems	1
		ENT problems	1
	Clinical Pharmacy1	Oral hygiene, mouth ulcer	1
		Obesity and body weight control.	1
		– Pain and musculoskeletal disorders	1
		Nicotine replacement therapy ( NRT).	1
		Dietary supplements	1
		An update in reclassification of OTC drugs ( simvastatin, Tamusotisin & azithromycin).
			2
		Medication adherence and errors.	1
		Introduction to biopharmaceutics.	2
	Biopharmaceutics	Biopharmaceutic aspects of products; drug absorption;	6
		mechanisms of
		absorption; physicochemical factors; dissolution rate; effects of excipients; type of dosage forms.
		One compartment open model.	2
		Multicompartment models.	2
		Pharmacokinetics of drug absorption.	2
		Bioavailability and bioequivalence.	2
		Clearance of drugs from the biological systems.	2
		Hepatic elimination of drugs.	2
		Protein binding of drugs.	2
		Intravenous infusion	2
		Multiple dosage regimens.	2
		Non-linear pharmacokinetics.	2
		Dosage adjustment in renal diseases.	2
		Introduction: The scope and concerns of public health, health care system in Iraq	1
		Measuring, Monitoring, and Evaluating the Health of a Population	1
		Population screening and public health	1
		Prevention and control of non-communicable diseases	1
		Principles of infectious disease control	1
		National immunization plan of Iraq.	1
		Communicable diseases (infections through the gastro-intestinal tract, Infections through skin and mucous membranes, Infections through the respiratory tract)	1
		Prevention and control of public health hazards ( Tobacco, alcohol, Public health aspects of illicit psychoactive drug use)	1
		Major health problems (Obesity, Physical activity and health, Public mental health and suicide, Dental public health, Sexually transmitted infections, Chronic hepatitis and other liver disease, Tuberculosis …)	2
		Nutritional disorders	1
		Family health	1
		Environmental health	1
		Occupational health	1
	Public Health	Travel health	1
		Introduction: a historic background of pharmacy practice.	1
		Pharmacy Practice and the health care system	2
		Health promotion in community pharmacy	1
		Introduction to Pharmaceutical care	1
		Pharmaceutical care planning	2
		Community pharmacy management	1
		Hospital pharmacy service.	1
		Biosafety in pharmacy practice	2
		Formulary management and Regulatory affairs	2
		Rational Use of Drugs	2
		Principles and Elements of Interpersonal Communication	2
	Communication Skills
	Communication Skills	Nonverbal type of communication.	2
		Barriers to communication.	2
		Listening and empathic responding during communication.	2
		Assertiveness.	2
		Interviewing and assessment.	2
		Helping patients to manage therapeutic regimens.	2
		Patient counseling; counseling check list; point-by-point
		discussion;
		counseling scenario.	2
		Medication safety and communication skills.	2
		Strategies to meet specific needs.	2
		Communicating with children and elderly about
		medications.	2
		Communication skills and inter-professional collaboration.	2
		Electronic communication in healthcare.	2
		Ethical behavior when communicating with patients.	2
		Travel health	1
		Health insurance	1
		Hormones of the pituitary and thyroid glands.	3
		Insulin and oral hypoglycemic drugs.	4
		Adreno-corticosteroids.	3
		The gonadal hormones and inhibitors.	3
		Autacoids and autacoid antagonists	3
		Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-	3
		inflammatory agents.
		Drugs used in erectile dysfunction.	2
		Drugs used in osteoporosis.	2
	Pharmacology III	Drugs used in the management of obesity.	2
		Cancer Chemotherapy: Anticancer drugs and	5
		immunosuppressants.
	Organic Pharmaceutical	β-Lactam antibiotics (Penicillins); β-Lactamase inhibitors;	9
	Chemistry III	Cephalosporins and Monobactams.
		Aminoglycosides and Chloramphenicol; Tetracylines; Macrolides;	9
		Lincomycins and Polypeptides; Antiviral agents (properties of viruses, viral classification, products).
		Sulfonamides (chemistry, nomenclature, mechanism of action,	4
		resistance, toxicity, side effects, metabolism, protein binding, distribution and SAR); products; Sulfones.
		Anti-neoplastic agents: Alkylating agents; Antimetabolites;	17
		Antibiotics; Plant products; Miscellaneous compounds.
		Hormones and related compounds; Future anti-neoplastic agents;	6
		Monoclonal antibodies; Gene therapy of cancer.
		Introduction to the concept of clinical pharmacy- its activities and professional responsibilities.( including current state of clinical pharmacy in Iraq) .	1
	Clinical Pharmacy II	overview of pharmaceutical care practice (the patient care
		process).	1
		Hematologic disorders: Anemia and sickle cell disease.	2
		Hypertension.	2
		Ischemic heart diseases	2
		Heart failure.	2
		Peripheral vascular diseases.	1
		– Asthma.	2
		Chronic obstructive pulmonary disease ( COPD ).	1
		Diabetes mellitus & Diabetic ketoacidosis (DKA) .	2
		Peptic ulcer disease.	2
		Tuberculosis	1
		Infective meningitis	1
		Respiratory tract infections	2
		GIT infections	1
		Gout and hyperuricemia	1
		Rheumatoid arthritis (RA) and osteoarthritis (OA)	2
		Osteoporosis and other metabolic bone disease.	1
		Infectious Endocarditis	1
		Surgical antibiotic prophylaxis	1
		Urinary tract infection (UTI)	1
		Introduction: general consideration; host factor, environmental	3
		factors
		of toxic effects.
		Carcinogenesis.	3
		Mutagenesis:	1
		Target organs and systemic toxicology; Respiratory system, Liver,	16
		Kidney, Skin, Nervous system, cardiovascular system, Blood.
	General Toxicology	Toxic substances: Food additive and contaminants, Pesticides,	15
		Metals,
		Radiation and radio active materials, plants, Solvents,
		Environmental toxicology: Air pollution, water and soil pollutants,	7
		Gases (Tear gas, Pepper spray), CO, Cyanide(H2S).
		Principles of pharmaceutical processing; mixing; fluid mixing;	7
		flow
		characteristics; mechanisms of mixing; mixing equipments; batch and continuous mixing; mixer selection; solid mixing theory and particulate solid variables; forces and mechanisms.
	Industrial Pharmacy I
		Milling; pharmaceutical application; size measurement methods;	7
		theory
		and energy of commenution; types of mills; factors influencing milling;
		selection of mill techniques; specialized drying methods.
		Drying: definition; purpose; humidity measurement; theory of	7
		drying;
		drying of solids, and classification of dryer; specialized drying methods.
		Clarification and filtration: Theory; filter media; filter aids;	7
		selection of
		drying method; non-sterile and sterile operations; integrity testing; equipments and systems (commercial and laboratory).
		Sterilization; validation of methods; microbial death kinetics;	7
		methods
		of sterilization (thermal and non-thermal); mechanisms; evaluation.
		Pharmaceutical dosage form design; pre-formulation; preliminary	3
		evaluation; bulk characterization; solubility and stability analysis.
		Pharmaceutical dosage forms; sterile products; development;	7
		formulation; production; processing; quality control.

	Fifth stage
		Lecture title
			hours
		Basic concept of prodrugs; Covalent bonds (cleavable); Prodrugs of	6
		functional groups; Types of prodrugs.
		Chemical delivery systems; Polymeric prodrugs; Types and structure
		of polymers; Cross-linking reagents.

	Organic Pharmaceutical Chemistry IV	Drug targeting.
			4
		Project.
			4
		Combinatorial chemistry; Peptides and other linear structures; Drug
		like molecules; Support and linker; Solution-phase combinatorial chemistry.
			5
		Detection, purification and analgesics; Encoding combinatorial
		libraries;
		High-throughput screening; Virtual screening; Chemical diversity and library design.	5
		Pharmaceutical dosage forms: Tablets; role in therapy; advantages
		and
		disadvantages; formulation; properties; evaluation; machines used in tableting; quality control; problems; granulation, and methods of production; excipients, and types of tablets.
			10
		Tablet coating; principles; properties; equipments; processing; types
		of
		coating (sugar and film); quality control, and problems.	4
		Capsules: Hard gelatin capsules; materials; production; filling
		equipments; formulation; special techniques.
			3
		Soft gelatin capsules: Manufacturing methods; nature of capsule shell
		and content; processing and control; stability.	2
		Micro-encapsulation; core and coating materials; stability;
	Industrial Pharmacy II	equipments
		and methodology.	2
		Modified (sustained release) dosage forms; theory and concepts;
		evaluation and testing; formulation.
			3
		Liquids: Formulation; stability and equipments.	3
		Suspensions: Theory; formulation and evaluation.
			3
		Emulsions: Theory and application; types; formulation; equipments
		and
		quality control.	3
		Semisolids: Percutaneouse absorption; formulation; types of bases
		(vehicles) preservation; processing and evaluation.
			3
		Suppositories: Rectal absorption; uses of suppositories; types of
		bases;
		manufacturing processes; problems and evaluation.	3
		Pharmaceutical aerosols: Propellants; containers; formulation; types
		and
		selection of components; stability; manufacturing; quality control and testing.	6
		Interpretation of Lab. data.	2
		Acute coronary syndrome.	2
	Therapeutic I	Arrhythmias	2
		Thrombosis	2
		Dyslipidemia	1
		Stroke	2
		Shock	2
		Liver cirrhosis	2
		Viral hepatitis	1
		Inflammatory bowel diseases	2
		Acute renal failure (ARF)	1
		Chronic renal failure (CRF)	2
		Hemodialysis and peritoneal dialysis	1
		Systemic lupus erythematosis (SLE)	1
		Benign prostatic hyperplasia (BPH)	1
		Acid – base disorders	2
		Disorders of fluid and electrolytes	2
		Urinary incontinence and pediatric enuresis	1
		Epilepsy and status epilepticus	2
		multiple sclerosis	1
		Parkinson’s disease	2
		Pain management	2
		Headache disorders	1
		glucoma	2
		Parenteral nutrition	2
		Enteral nutrition	2
		Pharmacovigilance	2
		Disorders of Carbohydrates metabolism, Hyperglycemia & Diabetes
		mellitus, Hypoglycemia.
			3
		Disorders of lipid metabolism.
			2
		Liver Function Tests.
			4
	Clinical Chemistry	Kidney Function Tests.
			4
		Diagnostic enzymology.
			4
		Hypothalamus & pituitary endocrinology, disorders of anterior
		pituitary hormones, disorders of adrenal gland, hypopituitrism.
			8
		Reproductive system, disorders of gonadal function in males &
		females, biochemical assessment during pregnancy.
			5
		Tumor markers.
			4
		Drug interaction with laboratory Tests.
			2
		Disorders of calcium metabolism
			3
		Acid- Base Disorders.
			4
		Initial Evaluation and Management of the Poisoned Patient.	3
		Including pediatric poisoning and special consideration in the geriatric patient
		Drug Toxicity: Over the counter drugs; caffeine; theophylline;	3
		antihistamine and decongestant; non-steroidal anti-inflammatory drugs; vitamins.
		Prescription Medications: Cardiovascular drugs; beta blockers; ACE	13
		inhibitors; Digoxin; Calcium channel blocker; Antiarrhythmic agents; hypoglycemic drugs; Opiods; CNS depressants; tricyclic antidepressants; anti-cholinergic phenothiazines; CNS stimulant.
	Clinical Toxicology	Drug of Abuse: Opioids; Cocaine; phencyclidine; marijuana; Lysergic acid.	4
		Chemical and Environmental Toxins: Hydrocarbones; Household	3
		toxins; Antiseptic; Disinfectants; Camphor; moth repellents.
		Botanicals and plants-derived toxins: Herbal preparation; Toxic	4
		plants;
		Poisonous mushrooms.
		Project.	( 1
	عورفلا عيمج		hours )
			,
	Pharmacoeconomy	Course overview & basic principle of pharmacoeconomics	2
		Cost analysis	6
		Cost effectiveness analyses (CEA).	2
		1st mid-term examination.	2
		Cost utility analyses (CUA).	2
		Cost-benefit analysis (CBA)	2
		Critical assessment of economic evaluation	4
		2nd mid-term examination.	2
		Drug-focused versus disease-focused frame work for
		conducting
		pharmacoeconomic analyses.	2
		Introduction to epidemiology.	2
		Project presentation.	2
		Project presentation.	2
	Therapeutic Drug Monitoring	Review of basic pharmacokinetic (PK) and pharmacodynamic
		(PD)	2
		Clinical PK equations and calculations	3
		Clinical PK in special population and cases	3
		Clinical PK/PD for Aminoglycosides	2
		Clinical PK/PD for Vancomycin	2
		Clinical PK/PD for Digoxin	2
		Clinical PK/PD for Phenytoin	3
		Clinical PK/PD for other Anticonvulsants (e.g., Carbamazepine, Valproic Acid, Phenobarbitone/Primidone, Ethosuxsimide
			3
		Clinical PK/PD for Theophylline	2
		Clinical PK/PD for Immunossprasants (e.g., Cyclosporine,
		Tacrolimus	2
		Clinical PK/PD for other Cardiovascular agents (e.g., Lidocaine, Procainamide/N-Acetyl Procainamide
			2
		Clinical PK/PD of other drugs (e.g., Lithium), Anticancer agents, and Anticoagulats
			4
		Clinical Pharmacy Practice in Internal Medicine: Clinical observation of
			10
		cases; evaluation of the case sheets; case presentation; discussion and
		evaluation.
		Clinical Pharmacy Practice in Surgery wards: Clinical observation of

		cases; evaluation of the case sheets; case presentation; discussion and	5
	Hospital Training	evaluation.
		Clinical Pharmacy Practice in Gynecology and Obstetrics Ward:

		Clinical observation of cases; evaluation of the case sheets; case presentation; discussion and evaluation.	5
		Clinical Pharmacy Practice in Pediatric Ward: Neurology , Cardiology , GIT , Birth defects , Sepesis , Meningitis
			10
		Thyroid and parathyroid disorders	2
		Contraception	1
		Endometriosis	1
		Menstruation related disorders	1
	Therapeutic II	Hormonal replacement therapy (HRT)	2
		Cancer treatment and chemotherapy	2
		Leukemias	2
		Lymphomas and Multiple myeloma	2
		Breast and prostate cancers	2
		Adverse effects of chemotherapy	1
		Human immunodeficiency viruse	2
		Adrenal gland disorders	1
		Pituitary gland disorders	1
		Alzheimer’s disease	1
		Schizophrenia	2
		Depressive disorders	2
		Anxiety disorders	1
		Sleep disorders	1
		Bipolar disorders	2
		colorectal cancer	1
		Diagnostic test basics, collecting &transporting specimens,	4
		venipuncture, urine specimen, stool specimen.
		Biochemical tests: Fasting blood glucose, Post-prandial glucose, Oral	4
		glucose tolerance test.
		Blood urea, Blood creatinine, Creatinine clearance, Uric acid.	4
		Cholesterol, Lipoproteins, triglycerides.	4
		Blood proteins, Bilirubin.	4
		Calcium, Inorganic phosphate, Serum chloride	4
		Alkaline phosphatase, Acid phosphatase, Alanine amiotransferase,	4
		Aspartate aminotransferase, Lactate dehydrogenase, Creatine phosphokinase.
		Serological tests: VDRL, ASO- Titer, Hepatitis tests.	4
	Clinical Laboratory Training	C-reactive protein test, Rheumatic factor test, Rosebengal test,	4
		Typhoid
		fever test( Widal test), Pregnancy Test.
		General urine examination, urine specimen collection.	4
		Hematological tests: RBC count, Hb, PCV, RBC indices, WBC	4
		count,
		Platelets count.
		Blood typing, Coombs test, Bleeding time, ESR.	4
		Microbiological tests: culture and sensitivity tests, Staining methods	4
		Culture media, Enriched culture media for general use	4
		Tests for identification of bacteria, Disk diffusion tests of sensitivity	4
		to
		antibiotics, Choice of drugs for disk test, bacterial disease and their laboratory diagnosis.
		Biotechnology – introduction	1
		Formulation of biotechnology product (biopharmaceutical	4
		consideration) Microbial consideration- sterility-pyrogen viral decontamination Excipients of parentral products – solubility enhancer-anti adsorption agents buffer components-preservatives – osmotic agents
	pharmaceutical biotechnology	Route of administration Parentral route Oral route Alternative	5
		routes ( nasal-pulmonary-rectal-buccal transdermal )
		Pharmacokinetic of peptides and proteins Introduction Elimination	5
		of proteins (proteolysis-excretion-metabolism )
		Pharmaceutical consideration: The need for the dosage form.	1

		General consideration for the dosage form.	3
		Pre-formulation; physical description, microscopic examination.	2
		Melting point; phase rule; particle size; polymorphism; solubility.	2
		Permeability; pH; partition coefficient; pka; stability; kinetics; shelf	2
		life.
		Rate reaction; enhancing stability.	2
		Formulation consideration: Excipients; definition and types;	2
		appearance; palatability; flavoring.
		Sweetening; coloring pharmaceuticals; preservatives; sterilization;	2
		preservatives selection.
	Dosage form Design	Biopharmaceutical considerations: Principle of drug absorption;	4
		dissolution of the drugs.
		Bioavailability and bioequivalancy; FDA requirements.	3
		Assessment of bioavailability; bioequivalence among drug products.	3
		Pharmacokinetic principles: Half life; clearance; dosage regimen	4
		considerations.
		UV / visible spectroscopy; Sample handling and instrumentation;	6
		Characteristic absorption of organic compounds; Rules for calculation of lambda max and application; Application of UV/visible; spectroscopy; Problems and solutions.
	Advanced Pharmaceutical Analyses
		Infra Red spectroscopy (theory and H-bonding effect; Sampling	14
		techniques and interpretation of spectra; Characteristic group frequencies of organic compounds; Application of IR spectroscopy; Problems and solutions.
		H1 –Nucleomagnetic Resonance (NMR) and C13-NMR spectroscopy;	12
		Introduction, the nature of NMR absorption, chemical shifts and factors affecting them, information obtained from NMR spectra, more complex spin-spin splitting patterns, application of H1-NMR spectroscopy;
		C13-NMR spectroscopy: introduction and characteristics, DEPT C13- NMR spectroscopy.
		Mass spectroscopy: Introduction and interpreting Mass spectra;	11
		interpreting Mass spectra fragmentation patterns, Mass behavior of some common functional groups.
		elemental microanalysis CHNSO	2