Abstract Although single-cell RNA sequencing studies have begun to provide compendia of cell expression profiles, it has been difficult to systematically identify and localize all molecular cell types in individual organs to create a full molecular cell atlas. Here, using droplet- and plate-based…

Importance Gastroesophageal reflux disease (GERD) is defined by recurrent and troublesome heartburn and regurgitation or GERD-specific complications and affects approximately 20% of the adult population in high-income countries. Observations GERD can influence patients’ health-related quality of life and is associated with an…

Ageing of the population, together with population growth, has brought along an ample increase in the number of older individuals living with dementia and disabilities. Dementia is the main cause of disability in old age and promoting healthy brain ageing is considered…

Blood pressure (BP) in the office is often recorded without standardization of the technique of measurement. When office BP measurement is performed with a research-grade methodology, it can inform better therapeutic decisions. The reference-standard method of ambulatory BP monitoring together with the…

Abstract Objective In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of…

Abstract Evidence‐based management of analgesia and sedation in COVID‐19‐associated acute respiratory distress syndrome remains limited. Non‐guideline recommended analgesic and sedative medication regimens and deeper sedation targets have been employed for patients with COVID‐19 due to exaggerated analgesia and sedation requirements with extended…

NEW YORK — December 17, 2020 — Both hyperglycaemia and hypoglycaemia were associated with poor outcomes in patients with coronavirus disease 2019 (COVID-19), according to a study published in Diabetes Care. An analysis of 1,544 patients with COVID-19 from 91 hospitals in…

AbstractAccumulating evidence indicates that gut microorganisms have a pathogenic role in autoimmune diseases, including in multiple sclerosis1. Studies of experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)2,3, as well as human studies4,5,6, have implicated gut microorganisms in the development or severity…

Abstract The risk of cancer and associated mortality increases substantially in humans from the age of 65 years onwards1,2,3,4,5,6. Nonetheless, our understanding of the complex relationship between age and cancer is still in its infancy2,3,7,8. For decades, this link has largely been attributed…

A study published in JAMA Network Open shows that there was no maternal viremia, placental infection, or vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a cohort of pregnant women with coronavirus disease 2019 (COVID-19). In addition, compromised transplacental transfer of…