at Thursday, 05/12/2022,  College of Pharmacy at the University of Karbala discussed a master’s thesis entitled (The effect of genetic polymorphisms (ABO) on the activity of the angiotensin-converting enzyme and the response to candestan treatment in hypertensive patients in Karbala governorate(

The thesis submitted by the student (Doaa Mohsen Farhan) to obtain a master’s degree in pharmacology and toxicology aimed to investigate the relationship of genetic polymorphisms. ABOI rs495828 and ABOT rs8176740 and ABO phenotype in the same patient on ACE activity in Karbala governorate population of those with hypertension responding to candesartan therapy.

The thesis included 92 patients suffering from high blood pressure to participate in this study who take a candesartan 8 mg tablet orally once daily. The study talked about blood pressure disease, which is the main cause of cardiovascular diseases and may affect the individual at any age, but it is more common and significantly with age gradually. Significantly, there are factors affecting patients with pressure, where smoking is one of the most common risk factors, family history, obesity, diabetes, stress and increased salt consumption, and candesartan is widely used as a first-line drug for patients with high blood pressure, although treatment efficacy appears to vary. Among individuals in hypertensive patients, the level of angiotensin-converting enzyme in the plasma is directly related to the level of angiotensin 2, which leads to an increase in blood pressure.

The thesis concluded that candesartan treatment is not a good option for patients suffering from low levels of angiotensin 2. The study also found that there is a close relationship between blood type and the level of angiotensin-converting enzyme.

College of Pharmacy media