The use of three to five Tablespoonful per day of garlic ,olive and sesame oil mixture
can improve health of patients suffering from rheumatoid arthritis disease
Ali jalil Ali University of Karbala, College of pharmacy.
Key word: Rheumatoid arthritis, Garlic oil, Olive oil, Sesame oil, Erythrocytes sedimentation
rate, Rheumatoid factor, Neutrophiles , anti-cyclic citrullinated peptide antibody .
Received (December/2015) , Accepted (June/2016).
Abstract
Background: Rheumatoid arthritis (RA) is an autoimmune disease where the body immune system
attacks different normal joint tissues organs causing inflammation of the joint lining . Rheumatoid
arthritis still one of an important diseases affecting large population. Different kinds of medicine
where used but still the needs for extra herbal medicine that assist and improve patients movements
is needed for decreasing patients compliance. This study summarized the benefit of using Garlic,
Olive and Sesame oil (GOS) mixture on patients health though its anti-inflammatory and antibacterial
effects and this effect was seen after using mostly three to five tablespoonful/day. Such
results was confirmed by decreasing most of inflammatory markers (Erythrocyte sedimentation rate
(ESR), Rheumatoid factor (RF), Neutrophile count, anti-cyclic citrullinated peptide antibody (Anti-
CCP) level and bacterial growth) with improving patients health. Aim of the study: to study the
efficiency of garlic oil, olive oil and sesame oil mixture in treatment of Rheumatoid arthritis
disease. Methods: A 80 serum samples (27 women and 43 men; mean age 45.5 ± 13.8 years; range, 25-
74 years) of patients with sign and symptoms of Rheumatoid arthritis attending Karbala Teaching
Hospital for Rheumatology department were studied. The patients were divided into three groups
:1- Twenty- five rheumatic patients were advised to administer five tablespoonful / day from
mixture containing GOS oil . 2- Thirty-five rheumatic patients were advised to administer three
table spoonful/ day of mixture containing GOS oil.3- Twenty patients were advised to administer
one tablespoonful/ day of mixture containing GOS oil. All the groups were advised to use topical
ointments containing mixture of GOS oil for 30 days. Inflammatory blood marker like Erythrocyte
sedimentation rate (ESR) , Rheumatoid factor (RF), Neutrophile count and Anti-CCP level in
addition to bacterial growth was evaluated before and after administration of GOS oral and topical
mixture.
Results: The results demonstrated that the level of ESR was decreased upon oral (three and five
tablespoonful/day) and topical use of GOS mixture. While RF level decreased if the patients use
five tablespoonful/day compared to three tablespoonful/day which show slight decrease in RF
level. However, Neutrophiles count was also found to be reduced during administration of three
tablespoonful/day while dosing of five and one tablespoonful/day shows a similar level of
reductions.
Anti-cyclic citrullinated peptide antibody regarded one of specific test for diagnosis of RA
disease. Five tablespoonful/day the patients describe a slight decline in the curve compared
with (three tablespoonful/day) that will have a sharp decrease in Anti-CCP level with
subsequent improvement in patients health . However, one tablespoonful/day , have relatively a
similar effect on Anti-CCP level to that of five tablespoonful/day). Bacterial growth profile was
found in all patients to be reduced sharply upon using GOS mixture. This decrease mostly
associated with the use of (three tablespoonful/day, five tablespoonful/day and one
tablespoonful/day) respectively.
Kerbala journal of pharmaceutical sciences. No. (11) 2016 (مجلة كربلاء للعلوم الصيدلانية العدد ( 11
2
Conclusion: Administration of oral (three to five tablespoonful/day) of GOS mixture was found to
reduce sign and symptom of RA disease with subsequent improvement in patients health. Such
results was accompanied by decreased in RA blood marker (ESR, RF, Neutrophiles count and Anti-
CCP ) level. In addition, to the reduction in bacterial growth. However, a further study is required
to investigate the effect of GOS mixture in compared to other anti-rheumatic drugs effects.
استعمال ثلاثة الى خمسة ملاعق يوميا من مستحضر زيت الزيتون والثوم والسمسم يساعد في التخفيف من
مرض التهاب المفاصل الرثوي .
م .د. علي جليل علي الياسري (كلية الصيدلة / جامعة كربلاء )
الكلمات المفتاحية: التهاب المفاصل الرثوي, زيت الثوم , زيت الزيتون , زيت السمسم , نسبة ترسيب الكريات الدم الحمر , قياس عامل
التهاب المفصل الرثوي . كريات الدم البيض.
الخلاصة : مرض التهاب المفاصل الرثوي هو احد الامراض المناعية التي يهاجم فيها الجهاز المناعي الغضاريف الموجودة في
المناطق المفصلية مؤديا الى حدوث التهابات مفصلية حادة و يعتبرهذا المرض واحد من الامراض المهمة التي تصيب اعداد كبيرة
من المرضى في العالم . هناك عدة أنواع من العلاجات والتي تستعمل بكميات كبيرة والتي لها اعراض جانبية كثيرة لطالما يعاني
منها المرضى طويلا ومن هنا برزت الحاجة الى ايجاد علاجات طبيعية اخرى تعطي تقريبا نفس مفعول العلاج بالادوية وذات
اعراض جانبية اقل, لذا تم في هذا البحث تحضير مزيج فموي وموضعي مكون من زيوت الثوم والزيتون والسمسم بنسب معينة
واعطائه لمجموعة من المرضى بجرع مختلفة ولفترة شهروقد لوحظ ان اعطاء المرضى (ثلاثة الى خمسة ملاعق طعام يوميا مع
استخدام مستحضر دهني موضعي تم تحضيره من نفس الزيوت اعلاه ) كان له تأثير كبير حيث تحسنت حالات المرضى والذي
انعكس أيجابا مع نقصان قيم بعض العوامل المستخدمة في تشخيص المرض مثل عامل معدل الرواسب الكريات الحمراء , عامل
الروماتيد, عدد العدلات , مكافحة الببتيد السيترولينيتد الدوري و نقصان كبير في نمو البكتريا التي قد تتسبب في زيادة معدل
المرض وأخيرا فان العلاج الجديد لم يسجل أي أعراض جانبية .

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